Inhibition of Melanoma Cell-Intrinsic Tim-3 Stimulates MAPK-Dependent Tumorigenesis.
Tobias SchattonYuta ItohChristina MartinsErik RasbachPraveen SinghMariana SilvaKyla N MucciaroneMarkus Vincent HepptJenna Geddes-SweeneyKate StewartAnne BrandenburgJennifer LiangCharles J DimitroffMartin C MihmJennifer LandsbergChristoph SchlapbachChristine G LianGeorge F MurphyThomas S KupperMatthew R RamseySteven R BarthelPublished in: Cancer research (2022)
Tim-3 is a growth-suppressive receptor intrinsic to melanoma cells, the blockade of which promotes MAPK-dependent tumorigenesis and thus counteracts antitumor activity of T-cell-directed Tim-3 inhibition.