MAD2B Blunts Chronic Unpredictable Stress and Corticosterone Stimulation-Induced Depression-Like Behaviors in Mice.
Xiao-Lan WangCheng MiaoYanfang SuChun ZhangXianfang MengPublished in: The international journal of neuropsychopharmacology (2023)
Our results suggest an important role of neuronal MAD2B in the pathogenesis of depression via the miR-29b-3p/GRM4 signaling pathway. MAD2B could be a potential therapeutic target for depressive disorders.
Keyphrases
- stress induced
- signaling pathway
- depressive symptoms
- sleep quality
- high glucose
- drug induced
- bipolar disorder
- pi k akt
- high fat diet induced
- adipose tissue
- metabolic syndrome
- induced apoptosis
- endothelial cells
- oxidative stress
- climate change
- blood brain barrier
- heat stress
- subarachnoid hemorrhage
- endoplasmic reticulum stress