Hepatic iron is the major determinant of serum ferritin in NAFLD patients.
John D RyanAndrew E ArmitageJeremy F CobboldRajarshi BanerjeeOscar BorsaniPaola DongiovanniStefan NeubauerReza MorovatLai Mun WangSant-Rayn PasrichaSilvia FargionJane CollierEleanor BarnesHal DrakesmithLuca Vittorio ValentiMichael PavlidesPublished in: Liver international : official journal of the International Association for the Study of the Liver (2017)
While hyperferritinaemia is associated with markers of liver injury and insulin resistance, serum hepcidin and hepatic iron are the strongest predictors of ferritin levels. These findings highlight the role of disordered iron homeostasis in the pathogenesis of NAFLD, suggesting that therapies aimed at correcting iron metabolism may be beneficial.