Improved efficacy, tolerance, safety, and abuse liability profile of the combination of CR4056 and morphine over morphine alone in rodent models.

Emanuele SalaFlora FerrariMarco Lanza Chiara Milia Chiara Sabatini Albino BonazziEleonora ComiMiriam Borsi FranchiniGianfranco Caselli Lucio Claudio Rovati

Published in: British journal of pharmacology (2020)

We showed selective synergism between CR4056 and morphine as analgesics. Their combination showed an improved safety and abuse liability profile over morphine alone. CR4056 could be developed as an opioid-sparing drug in multimodal analgesia.

Keyphrases

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intimate partner violence
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electronic health record