Single-cell RNA-seq reveals novel interaction between muscle satellite cells and fibro-adipogenic progenitors mediated with FGF7 signalling.

Lu MaYingying MengYalong AnPeiyuan HanChen ZhangYongqi YueChenglong WenXin'e ShiJianjun JinGongshe YangXiao Li

Published in: Journal of cachexia, sarcopenia and muscle (2024)

Our scRNA-seq reveals a novel interaction between muscle FAPs and satellite cells mediated by FGF7-FGFR2. Exogenous FGF7 augments the proliferation of satellite cells and thus benefits muscle regeneration and counteracts age-related myopathy.

Keyphrases

rna seq
single cell
induced apoptosis
cell cycle arrest
skeletal muscle
stem cells
cell death
endoplasmic reticulum stress
oxidative stress
gene expression
high throughput
duchenne muscular dystrophy