Potentially modifiable factors of dofetilide-associated risk of torsades de pointes among hospitalized patients with atrial fibrillation.

Niyada NaksukAlan M SugrueDeepak PadmanabhanDanesh KellaChristopher V DeSimoneSuraj KapaSamuel J AsirvathamHon-Chi LeeMichael J AckermanPeter A Noseworthy

Published in: Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing (2018)

Excessive QTc prolongation and AF with rapid ventricular rate at time of dofetilide initiation (likely due to difficulty in measuring QT intervals), and diuretic therapy for acute heart failure were independent factors for dofetilide-related TdP risk. Based on these data, possible preventive strategies could be adapted for safety protocols among hospitalized patients.

Keyphrases

acute heart failure
heart failure
drug induced
left ventricular
electronic health record
weight gain
big data
amyotrophic lateral sclerosis
machine learning
body mass index
sensitive detection