Predictors of premature termination of cardiac surgery trials: insights from the Clinicaltrial.gov database.
Gianmarco CancelliCamilla S RossiMichele Dell'AquilaPolina MantajAina HirofujiGiovanni SolettiLamia HarikBusra CangutTalal Al ZaghariJordan LeithGiorgia FalcoMudathir IbrahimArnaldo DimagliMohamed RahoumaMario F L GaudinoPublished in: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2024)
Slow recruitment is the most common reason for premature termination of cardiac surgery trials. Trials on left ventricular assist device, valve surgery, aortic surgery, phase 2 trials and phase 4 trials are more likely to be terminated, while trials conducted in Asia and Europe are less likely to be terminated prematurely.