Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components.

Paula LindnerSøren Brøgger ChristensenPoul NissenJesper Vuust MøllerNikolai Engedal

Published in: Cell communication and signaling : CCS (2020)

Together, our results provide a new, integrated understanding of UPR signaling mechanisms and downstream mediators that induce cell death upon Tg-triggered, unmitigated ER stress. Video Abstract.

Keyphrases

cell death
cell cycle arrest
endoplasmic reticulum
binding protein
endoplasmic reticulum stress
simultaneous determination
protein protein
amino acid
mass spectrometry
breast cancer cells
high resolution
cell proliferation
tandem mass spectrometry