Comprehensive Search for Novel Circulating miRNAs and Axon Guidance Pathway Proteins Associated with Risk of ESKD in Diabetes.
Eiichiro SatakePierre-Jean SaulnierHiroki KobayashiManoj K GuptaHelen C LookerJonathan M WilsonZaipul I Md DomKatsuhito IharaKristina O'NeilBozena KrolewskiCaterina PipinoMeda E PavkovViji NairMarkus BitzerMonika A NiewczasMatthias KretzlerMichael MauerAlessandro DoriaBehzad NajafianRohit N KulkarniKevin L DuffinMarcus G PezzolesiC Ronald KahnRobert G NelsonAndrzej S KrolewskiPublished in: Journal of the American Society of Nephrology : JASN (2021)
This study reveals novel mechanisms involved in progression to ESKD and points to the importance of systemic factors in the development of diabetic kidney disease. Some circulating miRNAs and axon guidance pathway proteins represent potential targets for new therapies to prevent and treat this condition.