NOX1 is essential for TNFα-induced intestinal epithelial ROS secretion and inhibits M cell signatures.

Nai-Yun Hsu Shikha NayarKyle GettlerSayali TalwareMamta GiriIsaac AlterCarmen A ArgmannKsenija SabicTin Htwe ThinHuai-Bin Mabel KoRobert WernerChristopher TastadThaddeus S StappenbeckAline AzabdaftariHans Holm Uhlig Ling-Shiang Chuang Judy H Cho

Published in: Gut (2022)

NOX1 deficiency plus TNFα stimulation contribute to colitis through dysregulation of the stem cell niche and altered cell differentiation, enhancing basal lymphoplasmacytosis. Our findings prioritise ROS modulation for future therapies.

Keyphrases

reactive oxygen species
stem cells
rheumatoid arthritis
cell death
dna damage
cell therapy
high glucose
single cell
diabetic rats
current status
drug induced
ulcerative colitis
dna methylation
gene expression
mesenchymal stem cells
bone marrow