Aptamer proteomics of serum exosomes from patients with Primary Raynaud's and patients with Raynaud's at risk of evolving into Systemic Sclerosis.
Sonsoles Piera-VelazquezSimon T DillonXuesong GuTowia A LibermannSergio A JimenezPublished in: PloS one (2022)
Aptamer proteomic analysis of circulating exosomes identified differentially elevated or reduced proteins between Raynaud's Phenomenon at high risk of evolving into SSc and Primary Raynaud's Phenomenon patients. Some of these proteins are involved in relevant biological pathways that may play a role in SSc pathogenesis including enhanced inflammatory responses, immune cell activation, and endothelial cell and vascular abnormalities.
Keyphrases
- systemic sclerosis
- label free
- interstitial lung disease
- end stage renal disease
- mesenchymal stem cells
- gold nanoparticles
- stem cells
- ejection fraction
- newly diagnosed
- endothelial cells
- sensitive detection
- chronic kidney disease
- prognostic factors
- mass spectrometry
- peritoneal dialysis
- rheumatoid arthritis
- bone marrow
- patient reported outcomes
- patient reported