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Nuclear ribonucleoprotein RALY downregulates foot-and-mouth disease virus replication but antagonized by viral 3C protease.

Jin'en WuChao SunJunyong GuanSahibzada Waheed AbdullahXuefei WangMei RenLu QiaoShiqi SunHuichen Guo
Published in: Microbiology spectrum (2024)
The translation of FMDV genomic RNA driven by IRES element is a crucial step for virus infections. Many host proteins are hijacked to regulate FMDV IRES-dependent translation, but the regulatory mechanism remains unknown. Here, we report for the first time that cellular RALY specifically interacts with the IRES of FMDV and negatively regulates viral replication by blocking 80S ribosome assembly on FMDV IRES. Conversely, RALY-mediated inhibition is antagonized by the viral 3C protease by the ubiquitin-proteasome pathway. These results would facilitate further understanding of virus-host interactions and translational control during viral infection.
Keyphrases
  • disease virus
  • sars cov
  • transcription factor
  • copy number
  • gene expression
  • binding protein
  • dna methylation
  • genome wide