Nonlinear progression across the occult transition establishes cancer lethality.
Joshua D GinzelHenry ChapmanJoelle E SillsEdwin J AllenLawrence S BarakRobert D CardiffAlexander D BorowskyHerbert Kim LyerlyBruce W RogersJoshua C SnyderPublished in: bioRxiv : the preprint server for biology (2024)
Growth during the invisible phase of tumorigenesis is a nonlinear processField size and field growth rate are uncoupled from metastatic potentialOccult transition rates vary by genotypeNascent lethal lesions are currently undetectable.