A role for paracrine interleukin-6 signaling in the tumor microenvironment in prostate tumor growth.

Shu-Han YuJanielle P MaynardAjay M VaghasiaAngelo M De MarzoCharles G DrakeKaren S Sfanos

Published in: The Prostate (2018)

Our results are consistent with previous studies in prostate cancer patients demonstrating that paracrine IL-6 production in the tumor microenvironment may influence tumor growth. Additionally, these data provide evidence that elevated systemic IL-6 levels may be involved in tumor growth regulation in prostate cancer, and are not simply caused by or indicative of tumor burden.

Keyphrases

prostate cancer
radical prostatectomy
benign prostatic hyperplasia
electronic health record
risk factors
case control
machine learning
deep learning
drug induced