Childhood asthma and type 1 diabetes mellitus: A meta-analysis and bidirectional Mendelian randomization study.

Junyang XieGui ChenTianhao LiangAng LiWeixing LiuYiyan WangXiaofen WangXiaoxuan KuangDeMin HanWenjing LiaoLijuan SongXiaowen Zhang

Published in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2022)

Both meta-analysis and MR study suggested that childhood asthma was a risk factor for T1DM. No epidemiological or genetic evidence was found for an association of T1DM with asthma incidence. Further studies could be carried out to leverage this newfound insight into better clinical and experimental research in asthma and T1DM.

Keyphrases

chronic obstructive pulmonary disease
lung function
systematic review
allergic rhinitis
magnetic resonance
computed tomography
risk factors
dna methylation
early life
adipose tissue
air pollution
contrast enhanced
skeletal muscle
copy number
childhood cancer