Selection and optimization of nano-formulation of P-glycoprotein inhibitor for reversal of doxorubicin resistance in COLO205 cells.

Tapan K DashVenkata Sai Badireenath Konkimalla

Published in: The Journal of pharmacy and pharmacology (2017)

Curcumin reversed DOX resistance in COLO205 cells at low concentration and enhanced curcumin encapsulation in HP-β-CD was noted in presence of PVA. Further, it was observed that prepared HP-β-CD-encapsulated curcumin is equi-efficacious to nano-dispersed curcumin.

Keyphrases

induced apoptosis
cell cycle arrest
drug delivery
cell death
pi k akt