Persistence of cerebellar ataxia during chronic ethanol exposure is associated with epigenetic up-regulation of Fmr1 gene expression in rat cerebellum.

Russell S DulmanJames AutaGabriela M WandlingRyan PatwellHuaibo ZhangSubhash C Pandey

Published in: Alcoholism, clinical and experimental research (2021)

These results suggest that epigenetic regulation of Fmr1 and subsequent FMRP regulation of target mRNA transcripts constitute neuroadaptations in the cerebellum that may underlie the persistence of ataxic behavior during chronic ethanol exposure and withdrawal.

Keyphrases

gene expression
dna methylation
early onset
drug induced
binding protein