Silencing SHMT2 inhibits the progression of tongue squamous cell carcinoma through cell cycle regulation.

Yan LiaoFang WangYadong ZhangHongshi CaiFan SongJin-Song Hou

Published in: Cancer cell international (2021)

Overexpression of SHMT2 in TSCC indicated low survival rates, and was associated with aggressive behaviors of TSCC. It was also found to be involved in cell cycle regulation of TSCC cells. SHMT2 may serve as a novel prognostic indicator of TSCC.

Keyphrases

cell cycle
cell proliferation
squamous cell carcinoma
induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
transcription factor
lymph node metastasis
radiation therapy
locally advanced