Plasma p-tau181/Aβ 1-42 ratio predicts Aβ-PET status and correlates with CSF-p-tau181/Aβ 1-42 and future cognitive decline.

Christopher J FowlerErik StoopsStephanie R Rainey-SmithEugeen VanmechelenJeroen VanbrabantNele DewitKimberley MaurooPaul MaruffChristopher C RoweJurgen FrippQiao-Xin LiPierrick BourgeatSteven J CollinsRalph N MartinsColin L MastersJames D Doecke

Published in: Alzheimer's & dementia (Amsterdam, Netherlands) (2022)

ratio predicted both Aβ-PET status and cognitive decline, demonstrating potential as both a diagnostic aid and as a screening and prognostic assay for preclinical AD trials.

Keyphrases

cognitive decline
mild cognitive impairment
cerebrospinal fluid
pet ct
positron emission tomography
computed tomography
pet imaging
high throughput
current status
stem cells
mesenchymal stem cells
human health
single cell