Incorporation of amoxicillin-loaded microspheres in mineral trioxide aggregate cement: an in vitro study.
Fábio Rocha BohnsVicente Castello Branco LeituneIsadora Martini GarciaBruna GenariNélio Bairros DornellesSílvia Stanisçuaski GuterresFabricio Aulo OgliariMary Anne Sampaio de MeloFabrício Mezzomo CollaresPublished in: Restorative dentistry & endodontics (2020)
Lack of optimal concentrations of antibiotics at anatomical sites of the dental tissues is a hallmark of recurrent endodontic infections. Therefore, targeting the controlled release of broad-spectrum antibiotics may improve the therapeutic outcomes of current treatments. Overall, these results indicate that the carry of amoxicillin by microspheres could provide an alternative strategy for the local delivery of antibiotics for the management of tooth infections.