Induction of Scleroderma Fibrosis in Skin-Humanized Mice by Administration of Anti-Platelet-Derived Growth Factor Receptor Agonistic Autoantibodies.

Michele Maria Luchetti GentiloniGianluca MoronciniMaria Jose EscamezSilvia Svegliati BaroniTatiana SpadoniAntonella GriecoChiara PaoliniAda FunaroEnrico V AvvedimentoFernando LarcherMarcela Del RioArmando Gabrielli

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2017)

Our results provide the first in vivo demonstration of the fibrotic properties of anti-PDGFR agonistic antibodies. This bioengineered skin-humanized mouse model can be used to test in vivo the progression of the disease and to monitor response to antifibrotic drugs.

Keyphrases

growth factor
mouse model
systemic sclerosis
soft tissue
monoclonal antibody
wound healing
systemic lupus erythematosus
interstitial lung disease
high fat diet induced
metabolic syndrome
adipose tissue