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Combination of a Collagen Scaffold and an Adhesive Hyaluronan-Based Hydrogel for Cartilage Regeneration: A Proof of Concept in an Ovine Model.

Clara LevinsonEmma CavalliBrigitte von RechenbergMarcy Zenobi-WongSalim E Darwiche
Published in: Cartilage (2021)
This study demonstrates that the adhesive HA-TG hydrogel in a collagen scaffold shows good biocompatibility, supports in situ cartilage regeneration and preserves the surrounding cartilage. This proof-of-concept study shows the potential of this approach, which should be further considered in the treatment of cartilage lesions using a single-step procedure.
Keyphrases
  • tissue engineering
  • wound healing
  • extracellular matrix
  • stem cells
  • drug delivery
  • combination therapy
  • human health
  • climate change