Imaging cellular pharmacokinetics of 18F-FDG and 6-NBDG uptake by inflammatory and stem cells.
Raiyan Tripti ZamanSilvan TuerkcanMorteza MahmoudiToshinobu SaitoPhillip C YangFrederick T ChinMichael V McConnellLei XingPublished in: PloS one (2018)
hAMSCs were found to be 2-3× more sensitive to 18F-FDG molecule compared to hiPSCs/macrophages. However, macrophages exhibited the most sensitivity towards 6-NBDG. Based on this result, hAMSCs targeted with 18F-FDG could be more suitable for understanding the mechanisms behind successful therapy for treating MI patients by gathering information on cell migration, proliferation and differentiation.
Keyphrases
- cell migration
- stem cells
- pet ct
- pet imaging
- positron emission tomography
- end stage renal disease
- newly diagnosed
- high resolution
- signaling pathway
- computed tomography
- healthcare
- oxidative stress
- health information
- cell therapy
- mesenchymal stem cells
- mass spectrometry
- patient reported outcomes
- photodynamic therapy
- social media