Hepatic Intra-arterial Delivery of a "Trojan-horses" Gene Therapy: A Pilot Study on Rabbit VX2 Hepatic Tumor Model.

Olivier PellerinIkram AmaraMarc SapovalTchao MéachiCarole DéanPhilippe BeauneIsabelle de Waziers

Published in: Cardiovascular and interventional radiology (2017)

Intra-arterial delivery of transduced-MSCs is feasible and, after CPA injection, resulted in 78% tumor necrosis (p = 0.006) and less metastasis in a VX2 liver tumor model.

Keyphrases

gene therapy
mesenchymal stem cells