Physiologically-Based Pharmacokinetic Modeling of Macitentan: Prediction of Drug-Drug Interactions.
Ruben de KanterPatricia N SidhartaStéphane DelahayeCarmela GnerreJerome SegrestaaStephan BuchmannChristopher KohlAlexander TreiberPublished in: Clinical pharmacokinetics (2016)
This example of the application of PBPK modeling to predict drug-drug interactions was used to support the labeling of macitentan (Opsumit).