Gut Bacterial Metabolite Urolithin A Decreases Actin Polymerization and Migration in Cancer Cells.

Md AlauddinToshiyuki OkumuraJanet RajaxavierShayan KhozooeiSimone PöschelSatoru TakedaYogesh SinghSara Y BruckerDiethelm WallwienerAndré KochMadhuri S Salker

Published in: Molecular nutrition & food research (2020)

UA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization and migration. Thus, use of dietary UA in cancer prevention or as adjuvant therapy is promising.

Keyphrases

cell migration
papillary thyroid
squamous cell
squamous cell carcinoma
lymph node metastasis