Genetic characterization of dilated cardiomyopathy patients undergoing heart transplantation in the Chinese population by whole-exome sequencing.

Hong LianShen SongWenzheng ChenAnteng ShiHaobin JiangShengshou Hu

Published in: Journal of translational medicine (2023)

Based on WES, we provided a primary genetic spectrum of DCM patients undergoing HTx in the Chinese population. TTN and FLNC harbour the most P/LP variants. FLNC truncation may lead to severe clinical symptoms in DCM patients.

Keyphrases

patients undergoing
end stage renal disease
ejection fraction
newly diagnosed
copy number
chronic kidney disease
prognostic factors
early onset
peritoneal dialysis
genome wide
patient reported outcomes
gene expression