Association of promoter methylation status of NRF2 and PNPLA3 genes in alcoholic liver disease.

Sibin M KManish ManraiRanveer SinghBhasker MukherjeeYogendra MishraMukesh U SinghAmandeep SinghRakhi NegiG Bala ChandraAthira S VPratibha Misra

Published in: Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology (2023)

The present study showed that methylation status of NRF2 and PNPLA3 genes could not differentiate between subgroups of alcoholic liver diseases. However, the unmethylation of NRF2 promoter is associated with higher serum levels of GGT.

Keyphrases

genome wide
dna methylation
oxidative stress
gene expression
liver injury
transcription factor
genome wide identification
bioinformatics analysis
drug induced