KAT6A/YAP/TEAD4 pathway modulates osteoclastogenesis by regulating the RANKL/OPG ratio on the compression side during orthodontic tooth movement.

Kuang TanJiayi WangXinyu SuYunfei ZhengWeiran Li

Published in: Progress in orthodontics (2024)

Our study showed that the PDLSCs modulated osteoclastogenesis and increased the RANKL/OPG ratio under mechanical force through the KAT6A/YAP/TEAD4 pathway. KAT6A might be a novel target to accelerate OTM.

Keyphrases

bone loss
nuclear factor
inflammatory response