Cancer risks for other sites in addition to breast in CHEK2 c.1100delC families.
Maartje A C SchreursMarjanka K SchmidtAntoinette HollestelleMichael SchaapveldChristi J van AsperenMargreet G E M AusemsIrma van de BeekMarjoleine F BroekemaJ Margriet ColléeAnnemieke H van der HoutKim J A F van KaamFenne L KomdeurArjen R MensenkampMuriel A AdankMaartje J Hooningnull nullPublished in: Genetics in medicine : official journal of the American College of Medical Genetics (2024)
A significantly increased risk of CRC, and hematological cancers in women was found, starting at a younger age than expected. Currently, colorectal surveillance starts at age 45 in high-risk individuals. Our results suggest that some CHEK2 c.1100delC families might benefit from this surveillance as well; however, further research is needed to determine who may profit from this additional colorectal surveillance.