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Unfolded protein response markers Grp78 and eIF2alpha are upregulated with increasing alpha-synuclein levels in Lewy body disease.

Dominik HrabosIlaria PoggioliniLivia CivitelliEmilia GalliChris EsapaMart SaarmaPäivi LindholmLaura Parkkinen
Published in: Neuropathology and applied neurobiology (2024)
Our data suggest a strong but regionally specific change in Grp78 and eIF2α levels, which positively correlates with soluble α-synuclein levels. Additionally, MANF levels decreased in dopaminergic neurons in the substantia nigra. Our research suggests that endoplasmic reticulum stress activation is not associated with Lewy pathology but rather with soluble α-synuclein concentration and disease progression.
Keyphrases
  • endoplasmic reticulum stress
  • induced apoptosis
  • parkinson disease
  • oxidative stress
  • machine learning
  • small molecule
  • signaling pathway
  • amino acid
  • cell surface
  • deep learning
  • data analysis
  • deep brain stimulation