Metabolomic Signatures Associated With Pulmonary Arterial Hypertension Outcomes.
Hongyang PiLu XiaDavid D RalphSamuel G RaynerAli ShojaiePeter J LearySina A GharibPublished in: Circulation research (2023)
Distinct plasma metabolomic profiles are associated with RV dilation, mortality, and measures of disease severity in PAH. Polyamine, histidine, and sphingomyelin metabolic pathways represent promising candidates for identifying patients at high risk for poor outcomes and investigation into their roles as markers or mediators of disease progression and RV adaptation.
Keyphrases
- pulmonary arterial hypertension
- mycobacterium tuberculosis
- end stage renal disease
- pulmonary artery
- pulmonary hypertension
- ejection fraction
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- cardiovascular events
- type diabetes
- gene expression
- genome wide
- risk factors
- cardiovascular disease
- patient reported outcomes
- adipose tissue
- weight loss