Influence of UGT2B7, UGT1A4 and ABCG2 Polymorphisms on the Pharmacokinetics and Therapeutic Efficacy of Lamotrigine in Patients with Epilepsy.
Jing YangJinxingyi WangLijie NingChangsong WuYang LiuJie XiaYanping GuanQian LiuJianghuan ZhengPublished in: European journal of drug metabolism and pharmacokinetics (2024)
UGT1A4 rs2011425 and ABCG2 rs2231142 were correlated with lamotrigine concentrations. Lower lamotrigine trough concentration was found in the ineffective group and the troughs were associated with seizure outcomes.