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Proteomics couples electrical remodelling to inflammation in a murine model of heart failure with sinus node dysfunction.

Konstantin KahnertLuca SoattinRobert W MillsClaire WilsonSvetlana MauryaAndrea SorrentinoSami Al-OthmanRoman TikhomirovYordi J van de VegteFinn B HansenJonathan AchterWei HuMin ZiMatthew SmithPim van der HarstMorten S OlesenKristine Boisen OlsenJytte BannerThomas H L JensenHenggui ZhangMark R BoyettAlicia D'SouzaAlicia Lundby
Published in: Cardiovascular research (2024)
Collectively, we outline the protein and phosphorylation remodeling of SND in heart failure, we highlight a role for inflammation in electrophysiological remodelling of the sinus node, and we present galectin-3 signalling as a target to ameliorate SND in heart failure.
Keyphrases
  • heart failure
  • oxidative stress
  • lymph node
  • left ventricular
  • acute heart failure
  • cardiac resynchronization therapy
  • atrial fibrillation
  • mass spectrometry
  • small molecule
  • protein kinase