Proteomics couples electrical remodelling to inflammation in a murine model of heart failure with sinus node dysfunction.

Konstantin KahnertLuca SoattinRobert W MillsClaire WilsonSvetlana MauryaAndrea SorrentinoSami Al-OthmanRoman TikhomirovYordi J van de VegteFinn B HansenJonathan AchterWei HuMin ZiMatthew SmithPim van der HarstMorten S OlesenKristine Boisen OlsenJytte BannerThomas H L JensenHenggui ZhangMark R BoyettAlicia D'SouzaAlicia Lundby

Published in: Cardiovascular research (2024)

Collectively, we outline the protein and phosphorylation remodeling of SND in heart failure, we highlight a role for inflammation in electrophysiological remodelling of the sinus node, and we present galectin-3 signalling as a target to ameliorate SND in heart failure.

Keyphrases

heart failure
oxidative stress
lymph node
left ventricular
acute heart failure
cardiac resynchronization therapy
atrial fibrillation
mass spectrometry
small molecule
protein kinase