Immunoglobulin profile and B-cell frequencies are altered with changes in the cellular microenvironment independent of the stimulation conditions.
Dannielle K MooreGina R LeischingCandice I SnydersAndrea GutschmidtIlana C van RensburgAndre G LoxtonPublished in: Immunity, inflammation and disease (2020)
Our results suggest that humoral B-cell function and development was impaired likely due to a lack of costimulatory signals from other cell types. Thus, B-cell function should ideally be studied in a PBMC or whole blood fraction.