Wnt5a/β-catenin-mediated epithelial-mesenchymal transition: a key driver of subretinal fibrosis in neovascular age-related macular degeneration.
Dandan LiuJingxiao DuHai XieHaibin TianLixia LuChaoyang ZhangGuo-Tong XuJingfa ZhangPublished in: Journal of neuroinflammation (2024)
Our study reveals a reciprocal activation between Wnt5a and β-catenin to mediate EMT as a pivotal driver of subretinal fibrosis in nAMD. This positive feedback loop provides valuable insights into potential therapeutic strategies to treat subretinal fibrosis in nAMD patients.
Keyphrases
- epithelial mesenchymal transition
- age related macular degeneration
- cell proliferation
- transforming growth factor
- end stage renal disease
- stem cells
- signaling pathway
- ejection fraction
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- liver fibrosis
- vascular endothelial growth factor
- risk assessment
- climate change
- human health