Flow-dependent regulation of rat mesenteric lymphatic vessel contractile response requires activation of endothelial TRPV4 channels.
Jacques DuToitPeter BrothersMatthew StephensKeith KeaneFlavia Neto de JesusSimon RoizesPierre-Yves von der WeidPublished in: Microcirculation (New York, N.Y. : 1994) (2023)
Our findings demonstrate a critical role for TRPV4 in the decrease in contraction frequency induced in lymphatic vessels by increases in flow rate via the production and action of nitric oxide and dilatory prostanoids.