Activin a Receptor Type 2A Mutation Affects the Tumor Biology of Microsatellite Instability-High Gastric Cancer.
Kizuki YuzaMasayuki NagahashiHiroshi IchikawaTakaaki HanyuMasato NakajimaYoshifumi ShimadaTakashi IshikawaJun SakataShiho TakeuchiShujiro OkudaYasunobu MatsudaManabu AbeKenji SakimuraKazuaki TakabeToshifumi WakaiPublished in: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract (2021)
Our study demonstrated that gastric cancer patients with ACVR2A mutation have a significantly better prognosis than those without. Dysfunction of ACVR2A in MKN74 human gastric cancer cells caused less aggressive tumor biology, indicating the importance of ACVR2A in the progression of MSI-H tumors.