Heterogeneity of Repolarization and Cell-Cell Variability of Cardiomyocyte Remodeling Within the Myocardial Infarction Border Zone Contribute to Arrhythmia Susceptibility.
Matthew AmoniDylan VermoorteleSamaneh Ekhteraei-TousiRosa Doñate PuertasGuillaume GilbertMohamad YounessBernard ThienpontRik WillemsH Llewelyn RoderickPiet ClausKarin R SipidoPublished in: Circulation. Arrhythmia and electrophysiology (2023)
Heterogeneous cardiomyocyte remodeling in the BZ is driven by uniquely altered gene expression, related to heterogeneity in the local microenvironment, and translates to heterogeneous repolarization and arrhythmia vulnerability in vivo.