CTCF maintains regulatory homeostasis of cancer pathways.

Sarah J AitkenXimena Ibarra-SoriaElissavet KentepozidouPaul FlicekChristine FeigJohn C MarioniDuncan T Odom

Published in: Genome biology (2018)

This multi-dimensional genomic and epigenomic profiling of a Ctcf hemizygous mouse model system shows that chronic depletion of CTCF dysregulates steady-state gene expression by subtly altering transcriptional regulation, changes which can also be observed in primary tumors.

Keyphrases

gene expression
mouse model
papillary thyroid
dna methylation
squamous cell
transcription factor
copy number
young adults
genome wide