Long-term effect of stents eluting 6-mercaptopurine in porcine coronary arteries.
Matthijs S RuiterAlbert DoornbosVivian de WaardRobbert J de WinterNico J M AtteveltRob SteendamCarlie J M de VriesPublished in: Journal of negative results in biomedicine (2016)
In conclusion, although 6-MP was previously found to potently inhibit SMC proliferation, reduce inflammation and promote endothelial cell survival, thereby effectively reducing in-stent restenosis in rabbits, stents containing 300 μg 6-MP did not reduce stenosis and inflammation in porcine coronary arteries.