Human liver organoids generated with single donor-derived multiple cells rescue mice from acute liver failure.
Yun-Zhong NieYun-Wen ZhengMiyuki OgawaEtsuko MiyagiHideki TaniguchiPublished in: Stem cell research & therapy (2018)
These results demonstrate that functional LOs generated from single donor cells can improve the condition of ALF mice. Functional SDC-LO transplantation provides a promising novel approach for ALF therapy.
Keyphrases
- liver failure
- induced apoptosis
- cell cycle arrest
- hepatitis b virus
- high fat diet induced
- type diabetes
- metabolic syndrome
- oxidative stress
- cell proliferation
- insulin resistance
- intensive care unit
- cell therapy
- wild type
- mesenchymal stem cells
- drug induced
- pi k akt
- extracorporeal membrane oxygenation
- induced pluripotent stem cells