68Ga-labelled desferrioxamine-B for bacterial infection imaging.

Milos PetrikEva UmlaufovaVladislav RaclavskyAndrea PalyzovaVladimir HavlicekJoachim PfisterChristian MairZbynek NovyMiroslav PopperMarian HajduchClemens Decristoforo

Published in: European journal of nuclear medicine and molecular imaging (2020)

DFO-B can be easily radiolabelled with 68Ga and displayed suitable in vitro characteristics and excellent pharmacokinetics in mice. The high and specific uptake of [68Ga]Ga-DFO-B by P. aeruginosa and S. aureus was confirmed both in vitro and in vivo, proving the potential of [68Ga]Ga-DFO-B for specific imaging of bacterial infections. As DFO-B is used in clinic for many years and the estimated radiation dose is lower than for other 68Ga-labelled radiopharmaceuticals, we believe that [68Ga]Ga-DFO-B has a great potential for clinical translation.

Keyphrases

pet ct
high resolution
primary care
mass spectrometry
risk assessment
skeletal muscle
fluorescence imaging
insulin resistance