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Toll-Like Receptor-Dependent Immunomodulatory Activity of Pycnogenol®.

Annelies VerlaetNieke van der BoltBen MeijerAnnelies BreynaertTania NaessensProkopis KonstantiHauke SmidtNina HermansHuub F J SavelkoulMalgorzata Teodorowicz
Published in: Nutrients (2019)
This study showed that gastrointestinal metabolism of PYC reveals its biological activity as a potential inhibitor of TLRs signaling. The results suggest that metabolized PYC acts as a partial agonist of TLR1/2 and TLR2/6 in the presence of the microbiota-derived TLR agonists (retentate fraction) and that it possesses anti-inflammatory potential reflected by the induction of IL-10 from THP-1 macrophages (dialysate fraction).
Keyphrases
  • toll like receptor
  • inflammatory response
  • nuclear factor
  • immune response
  • anti inflammatory
  • human health
  • peritoneal dialysis