Wolff-Parkinson-White syndrome: De novo variants and evidence for mutational burden in genes associated with atrial fibrillation.
Zeynep H Coban-AkdemirWu-Lin CharngMahshid AzamianIngrid S PaineJaya PunethaChristopher M GrochowskiTomasz GambinSantiago O ValdesBryan CannonGladys ZapataPatricia P HernandezShalini JhangianiHarsha DoddapaneniJianhong HuFatima BorichaDonna M MuznyEric BoerwinkleYaping YangRichard A GibbsJennifer E PoseyXander H T WehrensJohn W BelmontJeffrey J KimChristina Y MiyakeJames R LupskiSeema R LalaniPublished in: American journal of medical genetics. Part A (2020)
Our findings show an increased burden of rare deleterious variants in genes linked to AF in WPW syndrome, suggesting that genetic factors that determine the development of accessory pathways may be linked to an increased susceptibility of atrial muscle to AF in a subset of patients.
Keyphrases
- atrial fibrillation
- copy number
- end stage renal disease
- left atrial
- catheter ablation
- genome wide
- oral anticoagulants
- newly diagnosed
- left atrial appendage
- chronic kidney disease
- direct oral anticoagulants
- heart failure
- case report
- peritoneal dialysis
- skeletal muscle
- risk factors
- coronary artery disease
- left ventricular
- transcription factor