Lower Airway Dysbiosis Augments Lung Inflammatory Injury in Mild-to-Moderate COPD.
Imran SulaimanBenjamin G WuMatthew ChungBradley IsaacsJun-Chieh J TsayMeredith HolubClea R BarnettBenjmain KwokMatthias C KuglerJake G NataliniShivani SinghYonghua LiRosemary SchlugerJoseph CarpenitoDestiny CollazoLuisanny PerezYaa KyerematengMiao ChangChristina D CampbellPhilip M HansbroBeno W OppenheimerKenneth I BergerRoberta M GoldringSergei B KoralovMichael D WeidenRui XiaoJeanine D'ArmientoJose C ClementeElodie GhedinLeopoldo N SegalPublished in: American journal of respiratory and critical care medicine (2023)
Lower airway dysbiosis in the setting of smoke exposure contributes to inflammatory injury early in COPD. Targeting the lower airway microbiome in combination with smoking cessation may be of potential therapeutic relevance.