Modified redox signaling in vasculature after chronic infusion of the insulin receptor antagonist, S961.
Kristen J BubbRebecca H RitchieGemma A FigtreePublished in: Microcirculation (New York, N.Y. : 1994) (2018)
Infusion of S961, an insulin receptor antagonist, results in the production of a mouse model of type 2 diabetes that may be useful for investigating redox signaling in the vasculature of insulin-resistant mice over the short term. It is limited by both the transient nature of the hyperglycemia and incomplete functional analogy to the human condition.