Rheumatoid arthritis macrophages are primed for inflammation and display bioenergetic and functional alterations.
Megan M HanlonTrudy McGarryViviana MarzaioliSuccess AmaechiQingxuan SongSunil NagpalDouglas J VealeUrsula FearonPublished in: Rheumatology (Oxford, England) (2022)
This study demonstrates a unique inflammatory and metabolic phenotype of RA monocyte-derived macrophages and identifies a key role for NAMPT and STAT3 signalling in regulating this phenotype.