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Rheumatoid arthritis macrophages are primed for inflammation and display bioenergetic and functional alterations.

Megan M HanlonTrudy McGarryViviana MarzaioliSuccess AmaechiQingxuan SongSunil NagpalDouglas J VealeUrsula Fearon
Published in: Rheumatology (Oxford, England) (2022)
This study demonstrates a unique inflammatory and metabolic phenotype of RA monocyte-derived macrophages and identifies a key role for NAMPT and STAT3 signalling in regulating this phenotype.
Keyphrases
  • rheumatoid arthritis
  • oxidative stress
  • disease activity
  • dendritic cells
  • ankylosing spondylitis
  • cell proliferation
  • interstitial lung disease
  • genome wide
  • gene expression