Regio- and Enantioselective Allylic Amination of Aliphatic MBH Adducts with N-Heteroaromatics.
Haixia WangLulu YuMingsheng XieJiang WuGuirong QuKuiling DingHai-Ming GuoPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2017)
Palladium-catalyzed regio- and enantioselective allylic amination of aliphatic Morita-Baylis-Hillman (MBH) adducts with N-heteroaromatic nucleophiles (e.g., benzimidazole, 4,5-diphenylimidazole, benzotriazole, and purines) was achieved by using a spiroketal-based diphosphine (SKP) ligand, and afforded a range of chiral, branched N-allyl products with high selectivity.