TfNHNHBoc as a SCF3 source for the sulfenylation of indoles.
Jing-Yu GuoRui-Han DaiWen-Cong XuRuo-Xin WuShi-Kai TianPublished in: Chemical communications (Cambridge, England) (2018)
An unprecedented use of trifluoromethanesulfonyl hydrazides as effective SCF3 sources has been established in the sulfenylation of indoles. A range of substituted indoles participated in CuCl-catalyzed oxidative sulfenylation reaction with TfNHNHBoc in the presence of dimethyl sulfoxide to furnish structurally diverse 3-indolyl trifluoromethyl thioethers in moderate to good yields with very high regioselectivity.